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Hyaluronic Acid Serum

Many companies sell hyaluronic acid serum as a skin topical. Hyaluronic acid serum is supposed to plump the skin and diminish wrinkles. Other companies sell HA as an oral supplement or as an injectable. Hyaluronic acid serum has a few uses besides cosmetics. Yale researches incorporated hyaluronic acid for fertility . A doctor might prescribe injections of hyaluronic acid into the knee to improve mobility. Tissue engineers are investigating ways to use hyaluronic acid in the creation of cartilage and bone.

 

Applications for Hyaluronic Acid

Tissue

Application

Skin

Reducing the Appearance of Wrinkles

Cartilage

Mobility, Tissue Engineering

Bone Marrow

Tissue Engineering

Cosmetic Uses for Hyaluronic Acid Serum
Many companies advertise HA as a beauty product. Sometimes it is sold as a hyaluronic acid serum that customers rub into the skin. Other times it is sold as a capsule that the customer ingests. Hylaform gel ® is an injected form of hyaluronic acid. It is injected right under the skin to temporarily reduce the appearance of wrinkles. Over time, the injected hyaluronic acid breaks down and the body absorbs it. Consumers need to keep going back for more injections if they depend on Hylaform gel ® for wrinkle reduction.

Joint and Bone Uses for Hyaluronic Acid Serum
A doctor might prescribe injections of hyaluronic acid to alleviate joint pain. Synvisc-One® was designed to reduce joint pain. The Synvisc One website advertises that one injection can relieve pain for up to six months. Always consult a medical professional before starting any injection regiment.

Because cartilage takes such a long time to heal naturally, biologists at the University of Pennsylvania investigated ways to fill in damaged sections of cartilages with engineered tissue. When tissue engineers build a tissue, they begin with a matrix which acts as a scaffold for the cells to cling to. Then they seed the matrix with partially developed cells. These cells attach to the matrix and differentiate into the specialized cells of the developed tissue. Researchers at the University of Pennsylvania studied how well certain immature cells behave in a hyaluronic acid matrix. The cells differentiated into the mature cells of cartilage and started producing the chemicals that make up the bulk of cartilage. A second study by this group measured how strongly cartilage made with this method would integrate into existing cartilage and how the density of the hyaluronic acid affects integration.

Cartilage is not the only engineered tissue that uses hyaluronic acid. Researchers at the University of Texas used a matrix of hyaluronic acid and a second polymer to simulate bone marrow. They seeded this matrix with cells that had the potential to become blood cells. Analysis of the gene expression in the cells indicated that they differentiated some but that they would not differentiate all the way into the desired blood cells.

Hyaluronic acid has many applications ranging from tissue scaffold to beauty product. Tissue engineers rely on hyaluronic acid when they create artificial tissues. Some people have injections of hyaluronic acid to help with mobility or to temporarily diminish wrinkles. Hyaluronic acid is also sold as an oral supplement or as a hyaluronic acid serum that can be rubbed into the skin.

References:

1. Summary of Safety and Effectiveness Data for Intra-articular Hyaluronic Acid. Food and Drug Administration
http://www.accessdata.fda.gov/cdrh_docs/pdf/P940015S012b.pdf

2. Hylaform® gel Explained. Food and Drug Administration
http://www.accessdata.fda.gov/cdrh_docs/pdf3/P030032d.pdf

3. Sperm-Hyaluronic Acid Interaction: Assessment of Male Fertility and Selection of Mature Sperm for ICSI. Ob/GYN Quarterly
Yale University School of Medicine
http://www.med.yale.edu/obgyn/advancing/summer08/spermhyaluronic.html

4. Translation of Engineered Cartilage: In Vitro Evaluation of Integration Capacity of MSC-Based Constructs. Penn Medicine
University of Pennsylvania
http://www.med.upenn.edu/orl/people/mauck/Resources/Final/cartintegration.pdf

5. Development of Hyaluronic Acid - poly(ethylene glycol) hydrogels towards hematopoietic differentiation of mouse embryonic stem cells. Digital Depository
University of Texas
http://repositories.lib.utexas.edu/handle/2152/ETD-UT-2009-08-313

6. Synvisc One. Genzyme Corporation
http://www.synviscone.com/