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Biocell Collagen II Review

Biocell Collagen II™ is sold by Biocell Technology LLC. Biocell Collagen II™ is advertised as a health and beauty product with multiple benefits.  The ingredients in Biocell Collagen II include hyaluronic acid and collagen II. Hyaluronic acid is used in cosmetics, fertility research, and tissue development. Collagen II is an abundant protein in many tissues. Along with chondrotin sulfate, these ingredients are the major components of Biocell Collagen II

While Biocell Collagen II claims to support younger skin, the research publicized by the company tends to be focused on joint support. It is not clear whether Biocell Collagen II has been clinically tested for skin benefit

Hyaluronic Acid in Biocell Collagen II
Hyaluronic acid has been researched in connection with wrinkles, sperm activity, and tissue engineering. Hyaluronic acid is a popular ingredient that is found in many skin cosmetics. Researchers at Yale used hyaluronic acid to winnow out higher quality sperm for in vitro fertilization. Biologists at both the University of Texas and the University of Pennsylvania incorporated hyaluronic acid into their engineered tissues. A matrix of hyaluronic acid provides the scaffolding that is then seeded with cells. These cells then develop into the mature tissue.

Collagen II in Biocell Collagen II
Collagen is an important part of skin and many other organs. About a quarter of the protein in the human body is collagen. Three amino acids called glycine, proline, and hydroxyproline combine to form collagen. Hydroxyproline is made from proline in a reaction that requires vitamin C. The glycine, proline, and hydroxproline in collagen make a triple helix. They look a bit like 3 interlocked spiral stair cases. Zooming out a bit, the collagen looks look long ropes. Strands of collagen attach to each other to form a mesh that keeps tissues together.

Collagen II is one type of collagen.  Each type of collagen has a slightly different chemical composition and structure, which gives it unique properties. Scientists name molecules in the order that they discover them. Because more abundant molecules are easier to discover, the most abundant forms of a molecule tend to be labeled with lower numbers. Although there are 16 types of collagen, collagen I, collagen II, and collagen III make up between 80% and 90% of the collagen in the body.

Fun Facts about Collagen
•    One fourth of the protein in the body is collagen
•    There are 16 types of collagen
•    The most common types of collagen are collagen I, collagen II, and collagen III
•    The body needs vitamin C to make a component of collagen

Biocell Technology LLC combines hyaluronic acid, collagen II, and chondrotin sulfate to make Biocell Collagen II. This product appears to have devoted most of its research to joint support.No published studies were found on wrinkles or aging skin with Biocell Collagen II.


1. Biocell Collagen II. Biocell Company Website

2. Collagen. RCSB Protein Data Bank

3. Sperm-Hyaluronic Acid Interaction: Assessment of Male Fertility and Selection of Mature Sperm for ICSI. Ob/GYN Quarterly
Yale University School of Medicine

4. Development of Hyaluronic Acid - poly(ethylene glycol) hydrogels towards hematopoietic differentiation of mouse embryonic stem cells. Digital Depository
University of Texas

5. Translation of Engineered Cartilage: In Vitro Evaluation of Integration Capacity of MSC-Based Constructs. Penn Medicine
University of Pennsylvania

6. Collagen: The Fibrous Proteins of the Matrix. Molecular Cell Biology
National Center for Biotechnology Information