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Injections for wrinkles

Injections for wrinkles or aging are offered by doctors and health spas . A person could get injections in the lips to make them plumper or he/she could get injections in the skin to diminish the appearance of wrinkles. The injected material is called  filler. Fillers can be synthetic, or they can be extracted from natural, biological sources. The fillers from biological sources tend to break down in the body more quickly than do the synthetic fillers. Biological sources for fillers include humans, cows, pigs, birds, and bacteria.

Injections for Wrinkles from Human Sources
The first cosmetic injections for wrinkles started a century ago. At that time, it was common for doctors to inject fat from a patient just below that patient's skin to smooth out wrinkles. This filler is called "autologous fat". "Autologous" means from the patients own body. Autologous fat is less popular today, but it is still in use by some doctors. The autologous fat normally comes from the patient's thighs or abdomen.

Collagen fillers can also come from human sources. Sometimes, the doctor sends a sample form the patient to a lab where it is turned into a collagen filler. At other times, the doctor will use collagen from the donated tissue of dead humans.

Injections for Wrinkles from other Species
Cows and pigs are two common sources of collagen for anti-aging injections. Fillers made of bovine (cow) collagen were developed in the 1980s. Fillers made from porcine (pig) collagen were developed later. Both types of collagen are similar to human collagen.

Hyaluronic acid is a filler that comes from birds or bacteria. It is a carbohydrate that is injected beneath the skin to plump it. In addition to cosmetic enhancement, hyaluronic acid is used to select more fertile sperm for in vitro fertilization. Hyaluronic acid also provides the scaffolding for cells to grow on during tissue engineering.

Injections for Wrinkles of Synthetic Fillers
Synthetic fillers tend to remain in the body longer. One synthetic filler consists of microbeads suspended in bovine collagen. Another synthetic filler is made of the same material as rain coats and boots. Sundry other synthetic molecules for anti-aging injections exist. 





The Patient

Autologous Fat, Collagen

Dead Humans







Hyaluronic Acid


Hyaluronic Acid

Synthetic Molecules

Reaction Chambers

There are many sources for the fillers used in age combating injections. Fillers can come from the patient, deceased humans, cows, pigs, birds, or bacteria. A doctor could also inject a synthetic filler. Know the source of a filler when you are considering cosmetic injections for wrinkles.


1. Reversible vs. Nonreversible Fillers in Facial Aesthetics: Concerns and Considerations. Dermatology Online Journal
University of California, Davis

2. Lip Augmentation. Cleveland Clinic

3. Perlane®. Food and Drug Administration

4. Hylaform® gel Explained. Food and Drug Administration

5. Sperm-Hyaluronic Acid Interaction: Assessment of Male Fertility and Selection of Mature Sperm for ICSI. Ob/GYN Quarterly
Yale University School of Medicine

6. A Review of Minimally Invasive Cosmetic Procedures: Porcine Collagen. Medscape Today

7. Summary of Safety and Effectiveness Data for Intra-articular Hyaluronic Acid. Food and Drug Administration

8. Translation of Engineered Cartilage: In Vitro Evaluation of Integration Capacity of MSC-Based Constructs. Penn Medicine
University of Pennsylvania

9. Development of Hyaluronic Acid - poly(ethylene glycol) hydrogels towards hematopoietic differentiation of mouse embryonic stem cells. Digital Depository
University of Texas